Losing the ability to walk is a natural fear of many people with multiple sclerosis (MS). Although having the disease doesn't mean you will require a wheelchair, many people with MS experience walking-related problems at some time. Fortunately, a newly approved medication is making a huge difference in the lives of those with mobility problems.

The drug dalfampridine (sold under the brand name Ampyra) was approved by the U.S. Food and Drug Administration (FDA) in January 2010. It's the first and only FDA-approved drug to help people with MS with walking problems. And it offers significant benefits to some users.

'Walking Drug' Shows Impressive Results

In clinical studies, Ampyra improved mobility in more than 30 percent of participants with MS. This includes men and women at all stages of the disease. Those who responded to the drug experienced significant improvement in walking speed and leg strength. For example, walking speeds increased by 25 percent compared with those who took a placebo.

What's more, some users of Ampyra report improvements in MS symptoms other than walking. These include cognitive function, fatigue, arm function, and vision. However, these benefits haven't yet been studied.  

How It Works

Taken in 10mg pills twice a day, Ampyra targets nerve fibers that have been damaged by MS. The drug works by blocking tiny pores on the fibers, preventing the outward flow of potassium. This stabilizes potassium levels within the fiber and improves the conduction of nerve signals, improving mobility problems.

To date, there are no known long-term health risks associated with taking Ampyra. However, it shouldn't be taken by those with a history of seizures or serious kidney problems. Women who are pregnant or breastfeeding also shouldn't take Ampyra.

Identifying Walking Problems

If you struggle with walking problems, it's important to talk with your doctor. Ampyra may be an option if your issues stem from nerve problems. Users should begin seeing results two to four weeks after beginning therapy. Your doctor may advise you to stop the medication if you haven't improved after six weeks.

However, many people with MS experience walking problems for reasons other than nerve damage. Some people have limited endurance because of fatigue. Visual problems can also cause problems walking. A physical therapist who specializes in treating people with MS can help identify these causes. He or she can also help treat the source of the problem with exercises and strategies involving assistive devices.

Key Takeaways

• Dalfampridine (brand name Ampyra) is the first and only FDA-approved drug to help people with MS with walking problems.

• Ampyra targets nerve fibers that have been damaged by MS.

• In clinical studies, Ampyra improved mobility problems in more than 30 percent of participants with MS.